Analysis of Potential Antihypertensive Drug Interactions in Outpatient Hypertension Patients at Arifin Achmad Hospital, Riau Province
Abstract
Hypertension is a cardiovascular disease that tends to increase every year. If left untreated, it can lead to complications and polypharmacy which is at risk of causing drug interactions, one of the most common DRPs that affect patient therapy outcomes. This study aims to analyze the use of antihypertensive drugs and potential drug interactions of outpatient hypertensive patients at RSUD Arifin Achmad Pekanbaru. This study is a retrospective descriptive study with 351 patien using Stockley Drug Interaction edition 8 literature and drugs.com application. The results showed of hypertensive was 67% female and 33% male. The highest age range was 56-65 years (37%). The most common drug combination was amlodipine and bisoprolol as 63 patients and the most common class of (CCB) (36%). Outpatient hypertension patients who experienced drug interactions were 294 patients (84%) and there were no drug interactions 57 patients (16%). Drug interactions based on severity were major 10%, moderate 70% and minor 20%. Based on the mechanism pharmacodynamic interactions 68%, pharmacokinetic 20% and unknown 12%.
References
[2] Mayangsari, Elly., Bayu Lestari., and Nurdiana, Farmakoterapi Kardiovaskuler. Malang: UB Press, 2019
[3] Kemenkes RI. 2023. Hipertensi Disebut sebagai Silent Killer, Menkes Budi Imbau Rutin Cek Tekanan Darah. Diakses pada tanggal 15 April 2024 dari https://sehatnegeriku.kemkes.go.id/baca/rilismedia/20230607/0843182/hipertensi-disebut-sebagai-silent-killer-menkes-budi-imbau-rutin-cek-tekanan-darah/
[4] Dinkes Riau, Profil Kesehatan Provinsi Riau Tahun 2022. Pekanbaru: Dinas Kesehatan Provinsi Riau, 2022
[5] Susanti, R., Renggana, H., Sadino, A., Rikardo, R., Sujana, D., & Farhan, Z. “Kajian Interaksi Obat Antihipertensi pada Pasien Rawat Jalan di Klinik “X” Kabupaten Garut”. Jurnal Ilmu Farmasi Dan Farmasi Klinik, vol. 20. no. 1, pp. 37-42, Juni, 2023
[6] Khusna, N., & Murdiana Happy Elda. “Identifikasi Drug Related Problems (DRPs) Obat Antihipertensi Di Puskesmas Dharma Rini Temanggung”. Jurnal Farmasi dan Kesehatan Indonesia, vol.1, no. 2, pp.13–26, September, 2021.
[7] Mahamudu, Y. S., Citraningtyas, G., & Rotinsulu, H. “Kajian Potensi Interaksi Obat Antihipertensi Pada Pasien Hipertensi Primer di Instalasi Rawat Jalan RSUD Luwuk Periode Januari – Maret 2016”. Jurnal Ilmiah Farmasi, vol. 6, no.3, pp.1-9, Agustus, 2017.
[8] Setyoningsih, H., & Zaini, F. “Hubungan Interaksi Obat Terhadap Efektivitas Obat Antihipertensi Di RSUD dr. R. Soetrasno Rembang”. Cendekia Journal of Pharmacy, vol. 6, no.1, pp. 76–88, Mei, 2022.
[9] Bexter, K, Stockley’s Drug Interactions: Eight Edition, London: Pharmaceutical Press, 2008.
[10] Scott A., & Scott NG, “Mechanisms Of Drug Interactions”. Pharmacy Tech Topics, vol. 18, no. 13, Juli, 2013.
[11] Jauhari, Mustofa, F. L., Triwahyuni, T., & Prasetya, T. “Karakteristik Pasien Hipertensi Di Ruang Poli Rawat Jalan Rumah Sakit Pertamina Bintang Amin Bandar Lampung”. Jurnal Ilmu Kedokteran dan Kesehatan, vol. 10, no. 3, pp.1681-1692, Maret, 2023.
[12] Bell Kayce., June Twiggs., Bernie R, Hypertension : The Silent Killer: Updated JNC-8 Guideline Recommendations, Auburn University, Alabama Pharmacy Association, 2015.
[13] Baxter, K. Stockley’s Drug Interactions: a source book of interactions, their mechanisms, clinical importance and management. Choice reviews online, vol. 48, no. 03, pp.48-1222,2010.
[14] PERHI.Konsensus Penatalaksanaan Hipertensi. Jakarta: Ina SH, 2019.
[15] Refdanita & Sukmaningsih, V.Potensi Interaksi Obat Pasien Diabetes Melitus Tipe-2 dengan Hipertensi di Rumah Sakit "X" Periode 2019 Sainstech Farma, vol. 14, no. 1, pp. 47-53, 2021.
[16] Gunawan YC, Kajian Interaksi Obat Pada Peresepan Pasien Hipertensi Geritri di Instalasi Rawat Jalan Rumah Sakit Panti Nugroho Yogyakarta Periode Januari-Juni 2016, Depok: Sanata Dharma University, 2017.
[17] Gunawan YC. Kajian Interaksi Obat Pada Peresepan Pasien Hipertensi Geritri di Instalasi Rawat Jalan Rumah Sakit Panti Nugroho Yogyakarta Periode Januari-Juni 2016. Sanata Dharma University; 2017
[18] Drugs.com, Drug Interaction Checker. http://www.drugs.com/. Diakses Oktober 2024.
[19] Bexter, K. Stockley’s Drug Interactions: Eight Edition. London: Pharmaceutical Press, 2008
[20] Indriani, L., & Oktaviani, E. Kajian Interaksi Obat Antihipertensi Pada Pasien Rawat Inap di Salah Satu Rumah Sakit di Bogor, Indonesia. Majalah Farmasetika., 4(Suppl 1), pp. 212–219,2019.
