Anti-Inflammatory Effects of Kersen Leaf (Muntingia Calabura L.) Ethanol Extract on Wistar Male White Rats
Keywords:
ethanol extract Muntingia calabuara L., antiinflamation, Kersen leaf
Abstract
The research of the effect of ethanol extract of cherry (Muntingia calabura L.) leaf in white male rat has been done. The extract administrated orally by doses 100, 200 and 400 mg/kg BW and negative control group used natrium carboxy methyl cellulose 1%. As positive control group used acetosal 500 mg/kg BW. The inflamation induced by Karagen (1%) injected on the sole of rats. Inflamation volume measured with plestimometer after 7,14 and 21 days administration. The result showed that the Kersen leaf (Muntingia calabura L. ) extract by doses 100, 200 and 400 mg/kg BW can decrease the inflamation volume equal to acetosal 500 mg/kg BW after 21 days.
References
[1] Arum, Y. P., Supartono, Sudarmin (2012). Isolasi dan Uji Daya Antimikroba Ekstrak daun Kersen (Muntingia calabura L), Jurnal MIPA,35 (2), 165-174
[2] Yadav, D., Shinde Aruna, M., dan Chandrashekar, A. (2013). Antioxidant and in vivo Anti- hyperglycemic activity of Muntingia calabura laves extracts. Research Library, 5 (3), 427-435
[3] Suresh, K. (2012). Pharmacognostic evaluation in vitro anti oxidant and in vivo antiinflammatory studies of Muntingia calabura Linn.Journal of Global Trands in Pharmaceutical Sciences, (3),2230-7346
[4] Robbins, S. L., & Kumar, V. (1995).Buku ajarpatolagi I (Edisi 4). Diterjemahkan oleh Staf Pengajar Laboratorium patolagi Anatomik Falkultas Kedokteran Airlangga, Surabaya. Jakarta: Penerbit Buku Kedokteran EGC.
[5] Departemen Kesehatan Republik Indonesia. (2000). Parameter standar umun ekstrak tumbuhan obat (Edisi I). Jakarta: Direktorat Jenderal Pengawasan Obat dan Makanan, Direktorat Pengawasan ObatTradisional
[6] Departemen Kesehatan Republik Indonesia. (2008).Farmakope Herbal Indonesia (Edisi I), Jakarta: Departemen Kesehatan Republik Indonesia.
[7] Wientarsih, I., Madyastuti, R., Prasetyo, B. F., & Firnanda, D. (2012). Gambaran serum ureum & kreatin pada tikus putih yang diberi fraksi etil asetat daun alpukat. Journal Vateriner, 13, (1), 57-62.
[8] Vogel, H.G. (2002). Drug Discovery and evalution pharmacological assay. Springer Verleg. Berlind. Haidenlherg. p764-765.
[9] Yadav, A. S., Kumar, S., Yadav, P. (2012). Antiinflamatory activity off root, leaves and stem of Dipteracanthus patulus (Janq.) Ness (Acanthaceae). Asian Dacific Juornal of Tropical Biomedicune, (3), S187-S191
[10] Sabir, A. (2007). Inflammatory Response on Rat’s Dental Pulp Following Application of Propolis- Derived Flavonoids Extract. Dentika Dental Journal, 12, (1),2007.
[11] Mutsclher, Ernst. (1991). Dinamika Obat Farmakologi dan Toksikologi. Edisi kelima. Bandung. institut Teknologi Bandung.
[12] Uthia, R., Kardela, W., Transida, K.B. 2018. Uji Efek Antiinflamasi Ekstrak Etanol Daun Sambung Nyawa (Gynura procumbens (Lour.) Merr.) terhadap Kaki Tikus Putih Jantan. Jurnal Farmasi Higea, 10(1), 25-32
[2] Yadav, D., Shinde Aruna, M., dan Chandrashekar, A. (2013). Antioxidant and in vivo Anti- hyperglycemic activity of Muntingia calabura laves extracts. Research Library, 5 (3), 427-435
[3] Suresh, K. (2012). Pharmacognostic evaluation in vitro anti oxidant and in vivo antiinflammatory studies of Muntingia calabura Linn.Journal of Global Trands in Pharmaceutical Sciences, (3),2230-7346
[4] Robbins, S. L., & Kumar, V. (1995).Buku ajarpatolagi I (Edisi 4). Diterjemahkan oleh Staf Pengajar Laboratorium patolagi Anatomik Falkultas Kedokteran Airlangga, Surabaya. Jakarta: Penerbit Buku Kedokteran EGC.
[5] Departemen Kesehatan Republik Indonesia. (2000). Parameter standar umun ekstrak tumbuhan obat (Edisi I). Jakarta: Direktorat Jenderal Pengawasan Obat dan Makanan, Direktorat Pengawasan ObatTradisional
[6] Departemen Kesehatan Republik Indonesia. (2008).Farmakope Herbal Indonesia (Edisi I), Jakarta: Departemen Kesehatan Republik Indonesia.
[7] Wientarsih, I., Madyastuti, R., Prasetyo, B. F., & Firnanda, D. (2012). Gambaran serum ureum & kreatin pada tikus putih yang diberi fraksi etil asetat daun alpukat. Journal Vateriner, 13, (1), 57-62.
[8] Vogel, H.G. (2002). Drug Discovery and evalution pharmacological assay. Springer Verleg. Berlind. Haidenlherg. p764-765.
[9] Yadav, A. S., Kumar, S., Yadav, P. (2012). Antiinflamatory activity off root, leaves and stem of Dipteracanthus patulus (Janq.) Ness (Acanthaceae). Asian Dacific Juornal of Tropical Biomedicune, (3), S187-S191
[10] Sabir, A. (2007). Inflammatory Response on Rat’s Dental Pulp Following Application of Propolis- Derived Flavonoids Extract. Dentika Dental Journal, 12, (1),2007.
[11] Mutsclher, Ernst. (1991). Dinamika Obat Farmakologi dan Toksikologi. Edisi kelima. Bandung. institut Teknologi Bandung.
[12] Uthia, R., Kardela, W., Transida, K.B. 2018. Uji Efek Antiinflamasi Ekstrak Etanol Daun Sambung Nyawa (Gynura procumbens (Lour.) Merr.) terhadap Kaki Tikus Putih Jantan. Jurnal Farmasi Higea, 10(1), 25-32
Published
2023-05-02
How to Cite
UthiaR., RzI., JannahF., ArifinH., & AfdhalH. (2023). Anti-Inflammatory Effects of Kersen Leaf (Muntingia Calabura L.) Ethanol Extract on Wistar Male White Rats. JPK : Jurnal Proteksi Kesehatan, 12(1), 1-6. https://doi.org/10.36929/jpk.v12i1.438
Section
Articles
