Study Literature: Role of Secretome Mesenchymal Stem Cell as Innovation in Burn Treatment
Keywords:
Secretome, Mesenchymal stem cell Adiposa Tissue, Burn Wound, Wound Healing, Sacr Tissue
Abstract
The purpose of this review was to determine the role of MSCs in burn management. Scientific publication databases such as Researchgate, Google Scholar, ScienceDirect, and Pubmed were used for literature searches. [(Secretome, Mesenchymal stem cell Adipose Tissue, Umbilical Cord, Bone Marrow) AND (Burn wound OR wound healing OR burn injury OR thermal injury)] are the keywords used. In ten studies, rats, mice, and humans were used as research subjects in randomized clinical trials to conduct synthetic analyses. MSC therapy involves the use of bone marrow, cord blood, and adipose tissue. MSC therapy heals burns by suppressing the inflammatory response and oxidative stress, stimulating angiogenesis, and causing closure and repair (remodeling). MSC therapy has also been shown to reduce scarring and contracture formation.
References
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[14] S. Alapure, B. V., Lu, Y., He, M., Chu, C. C., Peng, H., Muhale, F., ... & Hong, “Accelerate healing of severe burn wounds by mouse bone marrow mesenchymal stem cell-seeded biodegradable hydrogel scaffold synthesized from arginine-based poly (ester amide) and chitosan.,” Stem Cells Dev., vol. 27, no. 23, pp. 1605-1620., 2018.
[15] J. S. Kim, W. S., Park, B. S., Sung, J. H., Yang, J. M., Park, S. B., Kwak, S. J., & Park, “Wound healing effect of adipose-derived stem cells: a critical role of secretory factors on human dermal fibroblasts.,” J. Dermatol. Sci., vol. 48, no. 1, pp. 15-24., 2007.
[16] W. E. B. Walter, M. N., Wright, K. T., Fuller, H. R., MacNeil, S., & Johnson, “Mesenchymal stem cell-conditioned medium accelerates skin wound healing: an in vitro study of fibroblast and keratinocyte scratch assays.,” Exp. Cell Res., vol. 316, no. 7, pp. 1271-1281., 2010.
[17] B. S. Bhang, S. H., Lee, S., Shin, J. Y., Lee, T. J., Jang, H. K., & Kim, “Efficacious and clinically relevant conditioned medium of human adipose-derived stem cells for therapeutic angiogenesis.,” Mol. Ther., vol. 22, no. 4, pp. 862-872., 2014.
[18] B. S. Kwon, S. H., Bhang, S. H., Jang, H. K., Rhim, T., & Kim, “Conditioned medium of adipose-derived stromal cell culture in three-dimensional bioreactors for enhanced wound healing.,” J. Surg. Res., vol. 194, no. 1, pp. 8-17., 2015.
[19] D. Zhou, B. R., Xu, Y., Guo, S. L., Xu, Y., Wang, Y., Zhu, F., ... & Luo, “The effect of conditioned media of adipose-derived stem cells on wound healing after ablative fractional carbon dioxide laser resurfacing.,” Biomed Res. Int., 2013.
[2] J. T. and H. X. Mingyao Wang , Xinxuan Xu, Xiongxin Lei, “Mesenchymal stem cell-based therapy for burn wound healing,” Burn. Trauma, vol. 9, 2021.
[3] M. G. Abdul Kareem, N., Aijaz, A., & Jeschke, “Stem cell therapy for burns: story so far.,” Biol. Targets Ther., pp. 379-397., 2021.
[4] Z. A. (2021). Santoso, “Peran terapi mesenchymal stem cell (MSC) dalam penatalaksanaan luka bakar: sebuah tinjauan sistematis.,” Intisari Sains Medis, vol. 12, no. 3, pp. 927-933., 2021.
[5] Z. Yi, H., Wang, Y., Yang, Z., & Xie, “Efficacy assessment of mesenchymal stem cell transplantation for burn wounds in animals: a systematic review.,” Stem Cell Res. Ther., vol. 11, pp. 1-13., 2020.
[6] Z. Ahmadi, A. R., Chicco, M., Huang, J., Qi, L., Burdick, J., Williams, G. M., ... & Sun, “Stem cells in burn wound healing: A systematic review of the literature.,” Burns, vol. 45, no. 5, pp. 1014-1023., 2019.
[7] C. Li, Y., Xia, W. D., Van der Merwe, L., Dai, W. T., & Lin, “Efficacy of stem cell therapy for burn wounds: a systematic review and meta-analysis of preclinical studies.,” Stem Cell Res. Ther., vol. 11, no. 1, pp. 1-12., 2020.
[8] A. Abbas, O. L., Özatik, O., Gönen, Z. B., Ögüt, S., Entok, E., Özatik, F. Y., ... & Musmul, “Prevention of burn wound progression by mesenchymal stem cell transplantation: deeper insights into underlying mechanisms.,” Ann. Plast. Surg., vol. 81, no. 6, pp. 715-724., 2018.
[9] K. A. H. Abdel-Gawad, D. R. I., Moselhy, W. A., Ahmed, R. R., Al-Muzafar, H. M., Amin, K. A., Amin, M. M., ... & Abdou, “Therapeutic effect of mesenchymal stem cells on histopathological, immunohistochemical, and molecular analysis in second-grade burn model.,” Stem Cell Res. Ther., vol. 12, no. 1, pp. 1-16., 2021.
[10] M. Afzali, L., Mirahmadi-Babaheydari, F., Shojaei-Ghahrizjani, F., Rahmati, S., Shahmoradi, B., & Banitalebi-Dehkordi, “The effect of encapsulated umbilical cord-derived mesenchymal stem cells in PRPCryogel on regeneration of grade-II burn wounds.,” Regen. Eng. Transl. Med., pp. 1-11., 2020.
[11] D. K. Laksmitawati, D. R., Noor, S. U., Sumiyati, Y., Hartanto, A., Widowati, W., & Pratami, “The effect of mesenchymal stem cell-conditioned medium gel on burn wound healing in rat.,” Vet. World, vol. 15, no. 4, p. 841., 2022.
[12] M. A. Aryan, A., Bayat, M., Bonakdar, S., Taheri, S., Haghparast, N., Bagheri, M., Piryaei, A. and Abdollahifar, “Human bone marrow mesenchymal stem cell conditioned medium promotes wound healing in deep second-degree burns in male rats.,” Cells Tissues Organs, vol. 206, no. 6, pp. 317–329, 2018.
[13] M. Kawai, T., Katagiri, W., Osugi, M., Sugimura, Y., Hibi, H., & Ueda, “Secretomes from bone marrow–derived mesenchymal stromal cells enhance periodontal tissue regeneration.,” Cytotherapy, vol. 17, no. 4, pp. 369-381., 2015.
[14] S. Alapure, B. V., Lu, Y., He, M., Chu, C. C., Peng, H., Muhale, F., ... & Hong, “Accelerate healing of severe burn wounds by mouse bone marrow mesenchymal stem cell-seeded biodegradable hydrogel scaffold synthesized from arginine-based poly (ester amide) and chitosan.,” Stem Cells Dev., vol. 27, no. 23, pp. 1605-1620., 2018.
[15] J. S. Kim, W. S., Park, B. S., Sung, J. H., Yang, J. M., Park, S. B., Kwak, S. J., & Park, “Wound healing effect of adipose-derived stem cells: a critical role of secretory factors on human dermal fibroblasts.,” J. Dermatol. Sci., vol. 48, no. 1, pp. 15-24., 2007.
[16] W. E. B. Walter, M. N., Wright, K. T., Fuller, H. R., MacNeil, S., & Johnson, “Mesenchymal stem cell-conditioned medium accelerates skin wound healing: an in vitro study of fibroblast and keratinocyte scratch assays.,” Exp. Cell Res., vol. 316, no. 7, pp. 1271-1281., 2010.
[17] B. S. Bhang, S. H., Lee, S., Shin, J. Y., Lee, T. J., Jang, H. K., & Kim, “Efficacious and clinically relevant conditioned medium of human adipose-derived stem cells for therapeutic angiogenesis.,” Mol. Ther., vol. 22, no. 4, pp. 862-872., 2014.
[18] B. S. Kwon, S. H., Bhang, S. H., Jang, H. K., Rhim, T., & Kim, “Conditioned medium of adipose-derived stromal cell culture in three-dimensional bioreactors for enhanced wound healing.,” J. Surg. Res., vol. 194, no. 1, pp. 8-17., 2015.
[19] D. Zhou, B. R., Xu, Y., Guo, S. L., Xu, Y., Wang, Y., Zhu, F., ... & Luo, “The effect of conditioned media of adipose-derived stem cells on wound healing after ablative fractional carbon dioxide laser resurfacing.,” Biomed Res. Int., 2013.
Published
2023-05-31
How to Cite
Wulandari, D., Marlina, M., & Novita, R. (2023). Study Literature: Role of Secretome Mesenchymal Stem Cell as Innovation in Burn Treatment. JPK : Jurnal Proteksi Kesehatan, 12(1), 15-20. https://doi.org/10.36929/jpk.v12i1.635
Section
Literature Review
