Article Review: Immunomudulatory Activity of Pegagan Embun (Hydrocotyle sibthorpioides Lam.) Extract

  • Adrul Fauzan Prodi Farmasi Universitas Andalas, Padang, Indonesi
  • Yufri Aldi Prodi Farmasi Universitas Andalas, Padang, Indonesi
  • Salman Umar Prodi Farmasi Universitas Andalas, Padang, Indonesi
  • Afriwardi Afriwardi Prodi Farmasi Universitas Andalas, Padang, Indonesi
Keywords: Immunomodulatory, Hydrocotyle sibthorpioides Lam, Flavonoids

Abstract

Various kinds of diseases can be caused by exposure to objects that are not recognized by the body. To recognize these foreign objects, a good immune system is needed. Immunomodulators are substances used to exert an effect on the immune system. The function of an immunodulator in the body can be as an immunostimulant, namely by stimulating the function of the immune system. Immunostimulating compounds can be obtained from plants. One of the plants that can be used is pegagan embun (Hydrocotyle sibthorpioides Lam.). In Hydrocotyle sibthorpioides Lam. It contains flavonoid compounds which have immunomodulatory activity. This article review was conducted to obtain information related to the immunomodulatory potential of the Hydrocotyle sibthorpioides Lam plant. The writing method for making this research article review was a comparative method, namely taken from a collection of national journals and international journals. Various research results that have been obtained prove that the extract of Hydrocotyle sibthorpioides Lam. can potentially enhance the body's immune system due to the content of flavonoid compounds which function as natural immunomodulators.

References

K. G. Baratawidjaja and I. Rengganis, Imunologi Dasar, Edisi 11. Jakarta: Fakultas Kedokteran Universitas Indonesia, 2014.

M. Radji, Imunologi & Virologi. Jakarta Barat: PT. ISFI Penerbitan, 2015.

A. E. Sukmayadi, S. A. Sumiwi, M. I. Barliana, and A. D. Aryanti, “Aktivitas Imunomodulator Ekstrak Etanol Daun Tempuyung (Sonchus arvensis Linn.),” Indones. J. Pharm. Sci. Technol., vol. 1, no. 2, pp. 65–72, 2014

K. Dhama et al., “Effect of Immunomodulation and Immunomodulatory Agents on Health with Some Bioactive Principles, Modes of Action and Potent Biomedical Applications,” Int. J. Pharmacol., vol. 11, no. 4, pp. 253–290, 2015

Y. Aldi, F. Novelin, and D. Handayani, “Aktivitas Beberapa Subfraksi Herba Meniran (Phyllanthusniruri Linn.) terhadap Aktivitas dan Kapasitas Fagositosis Makrofag,” Sci. J. Farm. dan Kesehat., vol. 5, no. 2, pp. 92–96, 2015

K. G. Baratawidjaja and I. Rengganis, Imunologi Dasar, Edisi 8. Jakarta: Fakultas Kedokteran Universitas Indonesia, 2010

F. Yu, F. Yu, P. M. McGuire, R. Li, and R. Wang, “Effects of Hydrocotyle sibthorpioides extract on transplanted tumors and immune function in mice,” Phytomedicine Int. J. Phyther. Phytopharm., vol. 14, no. 2–3, pp. 166–171, 2007

Hasdianah, P. Dewi, Y. Peristiowati, and S. I. S, Imunologi: Diagnosis dan Teknik Biologi Molekuler. Yogyakarta: Nuha Medika, 2014.

ITIS (Integrated Taxonomic Information System),“ Hydrocotyle sibthorpioides Lam," 2020. [Online]. Available: https://www.itis.gov/servlet/SingleRpt/SingleRpt?search_topic=TSN&search_value=29521#null.

Y. A. Nugroho, “Efek Pemberian Kombinasi Buah Sirih (Piper betle L.) Fruit, Daun Miyana (Plectranthus scutellarioides (L.) R. BR.) Leaf, Madu, dan Kuning Telur terhadap Peningkatan Aktivitas dan Kapasitas Fagositosis Sel Makrofag,” Media Litbang Kesehat., vol. 22, no. 1, pp. 1–5, 2012.

A. Badrunasar and H. B. Santoso, Tumbuhan Liar Berkhasiat Obat. Bogor: Forda Press, 2016.

H. Febryantono, Siswanto, P. E. Santosa, and M. Hartono, “Pengaruh Pemberian Dosis Ekstrak Meniran (Phyllanthus niruri L) terhadap Titer Antibodi Newcastle Disease dan Avian Influenza pada Broiler Jantan,” J. Ris. dan Inov. Peternak., vol. 4, no. 1, pp. 52–58, 2020

Depkes RI, Farmakope Herbal Indonesia, Edisi II. Jakarta: Departemen Kesehatan Republik Indonesia, 2017.

O. Kayser, K. N. Masihi, and A. F. Kiderlen, “Review: Natural Products and Synthetic Compounds as Immunomodulators,” Expert Rev. Anti. Infect. Ther., vol. 1, no. 2, pp. 319–335, 2003

R. Kasim, M. R. Yunus, and Kalsum, “Formulasi Minuman Instan Cokelat sebagai Minuman Imunomodulator,” J. Ind. Has. Perkeb., vol. 12, no. 1, pp. 21-33, 2017

J. B. Harborne, Metode Fitokimia, Edisi kedua. Bandung: Institut Teknologi Bandung, 1987.

S. Noer, R. D. Pratiwi, and E. Gresinta, “Penetapan Kadar Senyawa Fitokimia (Tanin, Saponin dan Flavonoid) sebagai Kuersetin Pada Ekstrak Daun Inggu (Ruta angustifolia L.),” J. Eksakta, vol. 18, no. 1, pp. 19–29, 2018

Y. A. Larakhansa, “Uji Efek Ekstrak Etanol Pegagan Embun (Hydrocotyle sibthorpioides Lam.) terhadap Aktivitas dan Kapasitas Fagositosis Sel Makrofag dan Persentase Sel Leukosit Mencit Putih Jantan,” Skripsi, Fakultas Farmasi Universitas Andalas, Padang, 2020.

F. Wahyuni, Y. Aldi, and E. Husni, “The Effect of Standarized Extract Pegagan Embun (Hydrocotyle sibthorpioides Lam.) on Total Leukocyte and Percentage Leukocytes in Male White Mice Exposed to H5N1 Virus Antigen,” Int. J. Innov. Sci. Res. Technol., vol. 6, no. 7, pp. 975–979, 2021

Afriwardi, Y. Aldi, D. Dillasamola, Y. A. Larakhansa, and E. Badriyya, “Immunostimulatory Activities of Pegagan Embun (Hydrocotyle sibthorpioides Lam.) in White Male Mice.,” Pharmacogn. J., vol. 13, no. 2, pp. 368–375, 2021

S. Umar, N. P. Erman, Armenia, E. Badriyya, and Y. Aldi, “The Activities of Pegagan Embun (Hydrocotyle sibthorpioides Lam.) on TNF-α, Macrophages and Leukocytes Male White Mice Exposed by H5N1 Virus Antigens,” Pharmacogn. J., vol. 14, no. 2, pp. 253–261, 2022

Published
2023-05-31
How to Cite
FauzanA., AldiY., UmarS., & AfriwardiA. (2023). Article Review: Immunomudulatory Activity of Pegagan Embun (Hydrocotyle sibthorpioides Lam.) Extract. JPK : Jurnal Proteksi Kesehatan, 12(1), 21-26. https://doi.org/10.36929/jpk.v12i1.636