Correlation of Estradiol Concentration and Body Mass Index in Progestin Contraceptive User
Keywords:
Estradiol, Body Mass index, DMPA User
Abstract
One method of contraception that has high effectiveness is progestin contraception. One type of progestin, namely depot medroxyprogesterone acetate, can stimulate the appetite control center in the hypothalamus, causing an increase in appetite and body weight. The number that becomes the standard assessment to determine whether a body weight is classified as normal, underweight, overweight, or obese is the body mass index (BMI). This research aims to identify the relationship between estradiol levels and body mass index. This type of research is analytic. The research sample was 45 DMPA user. Data analysis used discriminant analysis. The results showed that estradiol levels of 56.4 ± 19.3 pg/mL tended to have normal BMI. Estradiol levels of 73.3 ± 47.7 pg/mL tend to be overweight. It can be concluded that there is no relationship between estradiol levels and body mass index.
References
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[2] Hawkesworth, S.and Prentice, A.M. Obesity in the Tropics. Philadelphia: Elsevier. 2014.A.
[3] G Hardman. Dalam Cucu Aisyah dkk. Dasar farmakologi terapan Goodman dan Gillman. Jakarta: EGC. 2008.
[4] Westhoff C, Jain JK, Milsom I, Ray A. Changes in Weight with Depot Medroxyprogesterone Acetate Sub Cutaneous Injection 104 mg/0,65 mL. Contraception, 2007, vol. 75, no.4, pp. 261-267.
[5] Dal’Ava N, Bahamondes L, Bahamondes MV, Bottura, BF, Monteiro. I. Body weight and Body Composition of Depot Medroxyprogesterone Acetate User. Contraception, 2014, vol. 90, no. 2, pp.182-187.
[6] Clark M.K, Dillon JS, Sowers M, Nichols S. Weight, Fat Mass, and Central Distribution of Fat Mass Increase when Women Use Depot Medroxyprogesterone Acetate for Contraception. International journal of obesity, 2005, vol. 29, no. 10, pp. 1252-1258.
[7] F Weigt, C, Hertrampf T, Kluxen FM, Flenker U, Hulsemann F, Fritzemeier, et al. Molecular Effects of ER Alpha- and Beta-Selective Agonist on Regulation of Energy Homeostasis in Obese Female Wistar Rat. Molecular and cellular endocrinology, 2013, vol. 377, no. 1-2, pp.147- 158.
[8] Okorodudu, D.O, Jumean MF, Montori VM, Romero-Corral A, Somers VK, Erwin PJ, et al. Diagnostic Performance of Body Mass Index to Identify Obesity as Defined by Adiposity: a Systematic Review and Meta- Analysis. International journal of Obesity, 2010, vol. 34, no. 5, pp. 791-799.
[9] Gruber, C.J, Tschuggue W, Schneeberger C, Huber JC. Production and Actions of Estrogens. N Engl J Med, 2002, vol. 346, no. 5, pp. 340-352.
[10] Gardner D.G, Shoback D. Greenspan’s and Clinical Endocronology. 8th edn. New York, 2011.
[11] Guyton A.C, Hall J.E. Dalam Irawati dkk, Buku Ajar Fisiologi Kedokteran. Edisi ke 11, Jakarta: EGC, 2012.
[12] Torgrimson BN, Meendering JR, Kaplan PF, Minson CT. DMPA and Endothelial function prior to and after acute oral, vagina and transdermal estradiol treatment. J. Hypertension, 2011, vol. 57, pp. 819-824
[13] Razali. R. Kadar Estradiol Serum pada pemakaian KB DMPA 1 tahun dan 3 tahun. Bagian Obstetri dan Ginekologi FK USU.
[14] Bakry S, Merhi ZO, Scalise TJ, Mahmoud MS, Fadiel, A, Naftolin F. Depot Medroxyprogesterone Acetate: an Update Archives of gynecology and obstetrics, 2009, vol. 278, no.1, pp. 1-12.
[15] Vickery. Z, Madden T, Zhao Q, Secura G, Allsworth JE, Peipert JF., Weight Change at 12 Months in User of Three Progestin-Only Oontraceptive Methods, J. Contraception, 2013, vol. 88, no. 4, pp. 503-508
[16] Lopez M, Tena-Sempere M., Estradiol and Brown Fat, Best Practice and Research Clinical Endocrinology & Metabolism, 2016, vol. 30, no. 4, pp. 527-536.
[17] Melmed S, Polonsky, Kenneth S, Larsen P, Kronenberg H. Williams, Textbook of Endocrinology. Philadelphia: Elsevier, 2016.
[18] Sherwood L. Dalam : Brahm U., Fisiologi Manusia dari Sel ke Sistem, Jakarta: EGC, 2011.
[19] Cowley MA, Smith RG, Diano S, Tschop M, Pronchuk N, Grove KL. The Distribution and mechanism of action of ghrelin in the CNS Demonstrates a novel hypothalamic circuit regulation energy homeostasis. Neuron, 2003, vol 37.
[20] Pérez-Pérez, A., Sánchez-Jiménez, F., Maymó, J., Dueñas, J.L., Varone, C. and Sánchez-Margalet, V. ‘Role of leptin in female reproduction’, Clinical Chemistry and Laboratory Medicine (CCLM), 2015, vol. 53, no. 1.
Published
2023-07-22
How to Cite
Susanti, A., Darwin, E., & Rita, R. (2023). Correlation of Estradiol Concentration and Body Mass Index in Progestin Contraceptive User. JPK : Jurnal Proteksi Kesehatan, 12(1), 58-63. https://doi.org/10.36929/jpk.v12i1.638
Section
Articles
