Literature Review: Effect of Pegagan Embun (Hydrocotyle sibthorpioides Lam.) Extract on NK and CD8 Cell Activity
Keywords:
Hydrocotyle sibthorpioides Lam, Imunomodulator, Sel NK, Sel CD8
Abstract
There have been many traditional plants used for treatment, one plant that is widely used by the community for treatment is Hydrocotile sibthorpioides L. which is efficacious as an immunomodulator. In this plant, there are flavonoid compounds, namely rutin which has activity to increase the body's immune system, especially in NK and CD8 cells. NK (Natural Killer) and CD8 (Cluster of Differentiation 8) cells are components of the immune system that play an important role in immunomodulatory activity. This article review was conducted to obtain information on the effect of Hydrocotile sibthorpioides L. extract on NK and CD8 cell activity in the body. The writing method in making this research article review is comparative, which is taken from a collection of national journals and international journals. Various research results that have been obtained state that Hydrocotile sibthorpioides L. extract can affect the activity of NK and CD8 cells in improving the immune system.
References
[1] Anna, Romauli, “Uji Efek Imunomodulator Ekstrak Etanol Herba Binara (Artemisia Vulgaris L.) Pada Tikus Jantan,” J. the University Institutional Respiratory, 2017. Medan: Universitas Sumatra Utara
[2] Hasdianah, Dewi, P., Peristiowati, Y., & Sentot Imam, Imunologi : “Diagnosis dan Teknik Biologi Molekuler”. Jakarta: Nuha Medika, 2014.
[3] Radji, M, “Imunologi & Virologi”. Jakarta: PT ISFI Penerbitan, 2010.
[4] Sudiono, J, “Sistem Kekebalan Tubuh”, Jakarta: Buku Kedokteran EGC, 2014.
[5] Kresno, S, “Imunologi: Diagnosis dan Prosedur Laboratorium”. Jakarta: FKUI Press, 2010.
[6] Nugroho, Y. A, “Efek Pemberian Kombinasi Buah Sirih (Piper bettle L.) Fruit, Daun Miyana (Plectranthus scutellarioides (L.) R.BR). Leaf, Madu dan Kuning Telur Terhadap Peningkatan Aktivitas dan Kapasitas Fagositosis Sel Makrofag G”, Media Litbang Kesehatan, 22(1), 1–5, 2012.
[7] Huang, Q., Zhang, S., Huang, R., Wei, L., Chen, Y., Lv, S., Liang, C., Tan, S., Liang, S., Zhuo, L., & Lin, X, “Isolation and identification of an anti-hepatitis B virus compound from Hydrocotyle sibthorpioides Lam” Journal of Ethnopharmacology, 150(2), 568–575, 2013, https://doi.org/10.1016/j.jep.2013.09.009.
[8] Bandrunasar, A., & Santoso, H. B, “Tumbuhan Liar Berkhasiat Obat”, Jakarta: Forda Press, 2016
[9] Afriwardi, Fitri, A., Husni, E., Badriyya, E., & Aldi, Y, “Immunostimulant Activity of Pegagan Embun Herbs Extract (Hydrocotyle sibthorpioides Lam.) With Carbon Clearance Method Towards Male White Mice”, Pharmacognosy Journal, 13, 1472–1477, 2021, https://doi.org/10.5530/pj.2021.13.187
[10] Erman, N. P, “Aktivitas Ekstrak Etanol Herba Pegagan Embun (Hydrocortyle sibthorpiodes Lam.) Terhadap TNF-α, Makrofag dan Leukosit Mencit Putih Jantan Yang Terpapar Antigen Virus H5N1,” Skripsi, Universitas Andalas, 2021.
[11] Aldi Y, Anjelia, R, “Aktivitas Ekstrak Etanol Tumbuhan Pegagan Embun (Hydrocotyle Sibthorpioides L.) Terhadap Haematopoietik Mencit Putih Jantan Anemia”, Skripsi, 2020.
[12] Hardini, H, “Uji Toksisitas Akut Ekstrak Etanol Pegagan Embun (Hydrocotyle Sibthorpioides Lam.) pada Mencit Putih Jantan”, Skripsi, Universitas Andalas Padang, 2022
[13] Latifah, W, “Uji Toksisitas Subakut Ekstrak Pegagan Embun (Hydrocotyle sibthorpioides L) Terhadap SGPT dan SGOT pada Tikus Putih Jantan”, Skripsi, Universitas Andalas Padang, 2021.
[14] Fitri A, Husni E, Badriyya E, ALdi Y, “Immunostimulant Activity of Pegagan Embun Herbs Extract (Hydrocotyle sibthorpioides Lam.L With Carbon Clearance Mehtods Towards male White Mice,” 2021;13(6): 1472-7.
[15] Afriwardi, Abdillah, R., Husni, E., Hardini, H., Zuler, K. T. S., Alianta, A. A., & Aldi, Y, “Subacute Toxicity Test of Hydrocotyle Sibthorpioides Lam. Extract on Histopathological Images of Liver and Kidney of White Male Mice,” Pharmacognosy Journal, 14, 619–626, 2022. https://doi.org/10.5530/pj.2022.14.144
[16] ITIS (Integrated taxonomic information system). Hydrocotyle sibthorpioides Lam. [Internet], 2020
[17] Nugroho, Y. A, “Efek Pemberian Kombinasi Buah Sirih (Piper bettle L.) Fruit, Daun Miyana (Plectranthus scutellarioides (L.) R.BR). Leaf, Madu dan Kuning Telur Terhadap Peningkatan Aktivitas dan Kapasitas Fagositosis Sel Makrofag G,” Media Litbang Kesehatan, 22(1), 1–5, 2012.
[18] U. S. Wahyuni F, Aldi Y, “Wahyuni F, Aldi Y, Umar S, “The Effect of Standarized Extract Pegagan Embun (Hydrocotyle sibthorpioides Lam.) on Total Leukocyte and Percentage Leukocytes in Male White Mice Exposed to H5N1 Virus Antigen,” Int. J. Innov. Sci. Res. Technol., vol. 7, no. 6, pp. 975-979, 2021.
[19] D. kesehatan RI, “Farmakope Herbal Indonesia (Edisi II),” Jakarta: Departemen Kesehatan Republik Indonesia, 2017.
[20] Dhama, K., Saminathan, M., Singh, M., & Karthik, K. “Effect of Immunomodulation and Immunomodulatory Agents on Health with some Bioactive Principles , Modes of Action and Potent Biomedical Applications.” International Journal of Pharmacology, 253–290, 2015. https://doi.org/10.3923/ijp.2015.253.290
[21] Ortuño-Sahagún, D., Zänker, K., Rawat, A. K. S., Kaveri, S. V, & Hegde, P, “Natural Immunomodulators. Journal of Immunology” Research, 2–4, 2017
[22] Baratawidjaja, K. G., & Rengganis, I, “Imunologi Dasar Edisi 11,” Badan Penerbit FKUI, 2014.
[23] Bottino, C., Castriconi, R., Moretta, L., & Moretta, A, “Cellular ligands of activating NK receptors,” Trends in Immunology, 26(4), 221–226, 2005. https://doi.org/10.1016/j.it.2005.02.007
[24] Gao, G. F., & Jakobsen, B. K, “Molecular interactions of coreceptor CD8 and MHC class I: the molecular basis for functional coordination with the T-cell receptor,” Immunology Today, 21(12), 630–636, 2000. https://doi.org/10.1016/s0167-5699(00)01750-3
[25] Abbas, A. K., Lichman, A. H., & Pillai, S, “Imunologi Dasar: Fungsi dan Kelainan Sistem Imun Edisi Kelima,” Elsevier, 2016.
[26] Bruunsgaard, H., Pedersen, A. N., Schroll, M., Skinhøj, P., & Pedersen, B. K, “Proliferative responses of blood mononuclear cells (BMNC) in a cohort of elderly humans: role of lymphocyte phenotype and cytokine production,” Clinical and Experimental Immunology, 119(3), 433–440, 2000. https://doi.org/10.1046/j.1365-2249.2000.01146.
[27] Orange, J. S., & Ballas, Z. K, “Natural killer cells in human health and disease,” Clinical Immunology (Orlando, Fla.), 118(1), 1–10, 2006. https://doi.org/10.1016/j.clim.2005.10.011
[28] Kumar, V., Robbins, S. L., & Cotran, R. S, “Buku Ajar Patologi,” Buku Kedokteran EGC, 2007.
[2] Hasdianah, Dewi, P., Peristiowati, Y., & Sentot Imam, Imunologi : “Diagnosis dan Teknik Biologi Molekuler”. Jakarta: Nuha Medika, 2014.
[3] Radji, M, “Imunologi & Virologi”. Jakarta: PT ISFI Penerbitan, 2010.
[4] Sudiono, J, “Sistem Kekebalan Tubuh”, Jakarta: Buku Kedokteran EGC, 2014.
[5] Kresno, S, “Imunologi: Diagnosis dan Prosedur Laboratorium”. Jakarta: FKUI Press, 2010.
[6] Nugroho, Y. A, “Efek Pemberian Kombinasi Buah Sirih (Piper bettle L.) Fruit, Daun Miyana (Plectranthus scutellarioides (L.) R.BR). Leaf, Madu dan Kuning Telur Terhadap Peningkatan Aktivitas dan Kapasitas Fagositosis Sel Makrofag G”, Media Litbang Kesehatan, 22(1), 1–5, 2012.
[7] Huang, Q., Zhang, S., Huang, R., Wei, L., Chen, Y., Lv, S., Liang, C., Tan, S., Liang, S., Zhuo, L., & Lin, X, “Isolation and identification of an anti-hepatitis B virus compound from Hydrocotyle sibthorpioides Lam” Journal of Ethnopharmacology, 150(2), 568–575, 2013, https://doi.org/10.1016/j.jep.2013.09.009.
[8] Bandrunasar, A., & Santoso, H. B, “Tumbuhan Liar Berkhasiat Obat”, Jakarta: Forda Press, 2016
[9] Afriwardi, Fitri, A., Husni, E., Badriyya, E., & Aldi, Y, “Immunostimulant Activity of Pegagan Embun Herbs Extract (Hydrocotyle sibthorpioides Lam.) With Carbon Clearance Method Towards Male White Mice”, Pharmacognosy Journal, 13, 1472–1477, 2021, https://doi.org/10.5530/pj.2021.13.187
[10] Erman, N. P, “Aktivitas Ekstrak Etanol Herba Pegagan Embun (Hydrocortyle sibthorpiodes Lam.) Terhadap TNF-α, Makrofag dan Leukosit Mencit Putih Jantan Yang Terpapar Antigen Virus H5N1,” Skripsi, Universitas Andalas, 2021.
[11] Aldi Y, Anjelia, R, “Aktivitas Ekstrak Etanol Tumbuhan Pegagan Embun (Hydrocotyle Sibthorpioides L.) Terhadap Haematopoietik Mencit Putih Jantan Anemia”, Skripsi, 2020.
[12] Hardini, H, “Uji Toksisitas Akut Ekstrak Etanol Pegagan Embun (Hydrocotyle Sibthorpioides Lam.) pada Mencit Putih Jantan”, Skripsi, Universitas Andalas Padang, 2022
[13] Latifah, W, “Uji Toksisitas Subakut Ekstrak Pegagan Embun (Hydrocotyle sibthorpioides L) Terhadap SGPT dan SGOT pada Tikus Putih Jantan”, Skripsi, Universitas Andalas Padang, 2021.
[14] Fitri A, Husni E, Badriyya E, ALdi Y, “Immunostimulant Activity of Pegagan Embun Herbs Extract (Hydrocotyle sibthorpioides Lam.L With Carbon Clearance Mehtods Towards male White Mice,” 2021;13(6): 1472-7.
[15] Afriwardi, Abdillah, R., Husni, E., Hardini, H., Zuler, K. T. S., Alianta, A. A., & Aldi, Y, “Subacute Toxicity Test of Hydrocotyle Sibthorpioides Lam. Extract on Histopathological Images of Liver and Kidney of White Male Mice,” Pharmacognosy Journal, 14, 619–626, 2022. https://doi.org/10.5530/pj.2022.14.144
[16] ITIS (Integrated taxonomic information system). Hydrocotyle sibthorpioides Lam. [Internet], 2020
[17] Nugroho, Y. A, “Efek Pemberian Kombinasi Buah Sirih (Piper bettle L.) Fruit, Daun Miyana (Plectranthus scutellarioides (L.) R.BR). Leaf, Madu dan Kuning Telur Terhadap Peningkatan Aktivitas dan Kapasitas Fagositosis Sel Makrofag G,” Media Litbang Kesehatan, 22(1), 1–5, 2012.
[18] U. S. Wahyuni F, Aldi Y, “Wahyuni F, Aldi Y, Umar S, “The Effect of Standarized Extract Pegagan Embun (Hydrocotyle sibthorpioides Lam.) on Total Leukocyte and Percentage Leukocytes in Male White Mice Exposed to H5N1 Virus Antigen,” Int. J. Innov. Sci. Res. Technol., vol. 7, no. 6, pp. 975-979, 2021.
[19] D. kesehatan RI, “Farmakope Herbal Indonesia (Edisi II),” Jakarta: Departemen Kesehatan Republik Indonesia, 2017.
[20] Dhama, K., Saminathan, M., Singh, M., & Karthik, K. “Effect of Immunomodulation and Immunomodulatory Agents on Health with some Bioactive Principles , Modes of Action and Potent Biomedical Applications.” International Journal of Pharmacology, 253–290, 2015. https://doi.org/10.3923/ijp.2015.253.290
[21] Ortuño-Sahagún, D., Zänker, K., Rawat, A. K. S., Kaveri, S. V, & Hegde, P, “Natural Immunomodulators. Journal of Immunology” Research, 2–4, 2017
[22] Baratawidjaja, K. G., & Rengganis, I, “Imunologi Dasar Edisi 11,” Badan Penerbit FKUI, 2014.
[23] Bottino, C., Castriconi, R., Moretta, L., & Moretta, A, “Cellular ligands of activating NK receptors,” Trends in Immunology, 26(4), 221–226, 2005. https://doi.org/10.1016/j.it.2005.02.007
[24] Gao, G. F., & Jakobsen, B. K, “Molecular interactions of coreceptor CD8 and MHC class I: the molecular basis for functional coordination with the T-cell receptor,” Immunology Today, 21(12), 630–636, 2000. https://doi.org/10.1016/s0167-5699(00)01750-3
[25] Abbas, A. K., Lichman, A. H., & Pillai, S, “Imunologi Dasar: Fungsi dan Kelainan Sistem Imun Edisi Kelima,” Elsevier, 2016.
[26] Bruunsgaard, H., Pedersen, A. N., Schroll, M., Skinhøj, P., & Pedersen, B. K, “Proliferative responses of blood mononuclear cells (BMNC) in a cohort of elderly humans: role of lymphocyte phenotype and cytokine production,” Clinical and Experimental Immunology, 119(3), 433–440, 2000. https://doi.org/10.1046/j.1365-2249.2000.01146.
[27] Orange, J. S., & Ballas, Z. K, “Natural killer cells in human health and disease,” Clinical Immunology (Orlando, Fla.), 118(1), 1–10, 2006. https://doi.org/10.1016/j.clim.2005.10.011
[28] Kumar, V., Robbins, S. L., & Cotran, R. S, “Buku Ajar Patologi,” Buku Kedokteran EGC, 2007.
Published
2023-11-09
How to Cite
Gusriyani, S., Aldi, Y., Umar, S., & Afriwardi, A. (2023). Literature Review: Effect of Pegagan Embun (Hydrocotyle sibthorpioides Lam.) Extract on NK and CD8 Cell Activity. JPK : Jurnal Proteksi Kesehatan, 12(2), 91-96. https://doi.org/10.36929/jpk.v12i2.644
Section
Literature Review
