JPK : Jurnal Proteksi Kesehatan https://jurnal.pkr.ac.id/index.php/JPK <p>JPK: Jurnal Proteksi Kesehatan [ ISSN : 2715-1115 (online) 2302-8610 (print)] is a double-blind peer-reviewed national journal published twice on May and November. It is dedicated to promoting scholarly exchange among teachers, practitioners and researchers in the field on health in the broadest sense such as public health, nursing, midwifery, medicine, pharmacy, health psychology, nutrition, health technology, health analysis, health information system, medical record, health law, hospital management, enviromental science, etc.<br><br> DOI: <a href="https://doi.org/10.36929/jpk">https://doi.org/10.36929/jpk</a>.<br>by the Poltekkes Kemenkes Riau located in Pekanbaru, Indonesia</p> <p>&nbsp;</p> en-US jpk@pkr.ac.id (Ira Oktaviani Rz) dita@pkr.ac.id (Adita Ratnawidi) Mon, 13 Nov 2023 00:00:00 +0000 OJS 3.1.1.2 http://blogs.law.harvard.edu/tech/rss 60 Guarantee the Confidentiality of Medical Data for Covid-19 Patients https://jurnal.pkr.ac.id/index.php/JPK/article/view/667 <p><span lang="EN-US">Hospitals as health services are obliged to maintain the confidentiality of patient medical information. Facts circulating in the community, and the identity of Covid-19 patients is being disseminated in order to track or trace the closest contacts or other people's contacts. The purpose of this study is to analyze the limits of what medical information on Covid-19 patients can be disclosed by the health service in fulfilling requests from interested parties, as well as the procedures for disclosing Covid-19 patient information in guaranteeing confidentiality aspects. The research method is descriptive using a cross-sectional survey design approach. The results showed that there were 3 types of medical information for Covid-19 patients that could be disclosed, namely: (1) a Negative Covid-19 certificate, (2) a Diagnostic certificate, and (3) submission of insurance forms for replacement purposes. The conclusion is that all applications for a Medical Certificate, whether a Covid-19 case or not, are required to fill out a Statement of Release of information, and third parties are required to include a Power of Attorney for the Release of Information and a photocopy of identity.</span></p> Riska Rosita, Agusta Pinta Kurnia Rizky, Rara Nur Salsabila ##submission.copyrightStatement## https://jurnal.pkr.ac.id/index.php/JPK/article/view/667 Mon, 13 Nov 2023 06:41:39 +0000 Correlation between Knowledge and Personal Hygiene Behavior among Female Adolescents during Menstruation: A Study at MTSN Binanga School https://jurnal.pkr.ac.id/index.php/JPK/article/view/671 <p><span lang="EN-US">Personal hygiene during menstruation is behavior related to maintaining health and efforts to maintain the cleanliness of the female area during menstruation. Adolescents who do not apply methods of caring for their reproductive areas during menstruation cause reproductive health problems such as sexual transmitted disease, cervical cancer and other reproductive health problems. One of the factors that influence the personal hygiene behavior of young women during menstruation is knowledge. Knowledge about personal hygiene influences behavior in maintaining and caring for reproductive health during menstruation. This study aims to determine correlation between knowledge and personal hygiene behavior of female adolescents during menstruation at MTs N Binanga school in 2022. This type of research used quantitative research, analytic survey methods with a cross-sectional design. The sample was 86 students of class IX students of MTs N Binanga school and used purposive sampling technique. Data collection using a questionnaire. Data analysis used the chi-square test. The results showed that respondents had good knowledge and positive behavior (84%) and respondents who had less knowledge and negative behavior (57%). With a p-value = 0.002 &lt;</span><span lang="EN-US">α</span><span lang="EN-US"> = 0.05, which means there was a correlation between knowledge and personal hygiene behavior of young women during menstruation. The conclusion of this study was that there was correlation between knowledge and personal hygiene behavior of young women during menstruation at MTs N Binanga school. From these results, it is suggested to young women to perform good personal hygiene during menstruation.</span></p> Yulina Dwi Hastuty, Nur Atika Nasution, Lestari Rahmah, Kumalasari Kumalasari ##submission.copyrightStatement## https://jurnal.pkr.ac.id/index.php/JPK/article/view/671 Wed, 29 Nov 2023 05:08:54 +0000 The Effect of Phoenix Dactylifera on Uterine Contraction in Labor https://jurnal.pkr.ac.id/index.php/JPK/article/view/723 <p><span lang="EN-ID">Cases of prolonged labor in women labor in the world are still relatively high. Inadequate uterine contractions are the leading cause of complications of maternal death worldwide. This study aimed to analyze the Effect of Phoenix Dactylifera on uterine contractions in birthing mothers. The method applied in this research was an experimental Pretest posttest control group design. In this study, there were 60 samples, which were divided into two groups. The Paired t-test results on uterine contractions during the pretest-posttest in the intervention group showed significant results, namely a value of 0.000. In the control group, uterine contractions during the pretest-posttest showed an AP value of 0.090. Uterine contractions increased (adequate) after the mothers were given dates.</span></p> Dinda Kartika, Finta Isti Kundarti, Mika Mediawati, Didien Ika Setyarini ##submission.copyrightStatement## https://jurnal.pkr.ac.id/index.php/JPK/article/view/723 Fri, 01 Dec 2023 04:42:45 +0000 Knowledge of Athlete Nutrition, Parents, and Macronutrients Intake of Karate Shindoka Athletes https://jurnal.pkr.ac.id/index.php/JPK/article/view/685 <p style="font-weight: 400;"><span lang="EN-US"><em>Athletes have a higher activity compared to ordinary people, so their nutritional needs are different and require specific attention with proper dietary arrangements to be able to meet their nutritional needs. Good nutritional knowledge is expected to influence the consumption of correct and appropriate foods so that athletes can meet their nutritional needs. It aims to support increased stamina so athletes can support their achievements well. This study aims to determine the level of nutritional knowledge of athletes, parents, and the macronutrient intake of karate athletes Shindoka Riau. The sampling technique was total sampling with 25 respondents aged 12-18. Data collection was using questionnaires and food recall 2x24 hours. The results showed that athletes were 88% less energy intake, 96% less carbohydrates, 88% less fat, and 68% less protein. The level of knowledge of athletes is less than 68%, and the level of knowledge of parents is sufficient, which is 52%. It concluded that most of the nutritional knowledge of athletes and their parents in the less category had nutrient intake in the less category</em>.</span></p> Roziana Roziana, Dewi Erowati, Fahma Rahmadani Siregar ##submission.copyrightStatement## https://jurnal.pkr.ac.id/index.php/JPK/article/view/685 Tue, 05 Dec 2023 07:02:37 +0000 Formulation and Characterization of Nanoemulsion Turmeric oil https://jurnal.pkr.ac.id/index.php/JPK/article/view/733 <p><em>Turmeric oil is an essential oil derived from turmeric (Curcuma domestica). Turmeric oil is known to have antiinflammatory, antibacterial, antifungal and antioxidant activities. Nanoemulsions have the advantage of improving drug absorption and bioavailability. The purpose of the formulation of this nanoemulsion is to know the characteristics of turmeric oil nanomulsions. The formula consists of F1 (5%), F2 (10%), and F3 (15%). The preparation assessment covers organoleptic, pH, viscosity, stability, particle size, and zeta potential. The nanoemulsion preparation is produced in a thick yellow, typical odor of turmeric oil, with a pH of 6.8-7, a viskosity of 23-29 Cps, transmission values of 43.3-74.6%, droplet sizes at F1, F2, F3 of 23.2 nm, 203.8 nm, and 298.7 nm and zeta values potentials F1, F2 - 18.5mV, F 2 - 13.4mv, and F3 -8,5mV, all of the formulas well physically stable by the cracking, sedimentation and tubidity.</em></p> Yan Hendrika, Zulikho Aulia, Dini Mardhiyani ##submission.copyrightStatement## https://jurnal.pkr.ac.id/index.php/JPK/article/view/733 Tue, 05 Dec 2023 07:42:23 +0000 Antioxidant Activity Assay of Black Turmeric (C. Caesia) Water and Ethanol Extracted Using DPPH https://jurnal.pkr.ac.id/index.php/JPK/article/view/790 <p><span lang="EN-US">Antioxidants are compounds that provide electrons; they function by donating an electron to oxidizing compounds, thereby inhibiting the activity of these oxidants. The objective of this study is to ascertain the presence of secondary metabolites and evaluate the antioxidant properties of water and methanol extracts obtained from black turmeric (C. caesia). The determination of antioxidant activity was conducted using the DPPH method with a microplate reader at a wavelength of 520 nm, by calculating the IC50 value. The research findings indicate that both water and methanol extracts contain flavonoids, saponins, and tannins. The antioxidant activity of the water extract measured at 392.47 ± 46.38 ppm (weaker), the methanol extract displayed a higher activity at 69.66 ± 2.91 ppm (strong), and Vitamin C exhibited very strong activity at 3.98 ± 0.26 ppm.</span></p> Sri Kartini, Pratiwi Susanti, Isty Maulia Marshanda, Denia Pratiwi, Dini Mardhiyani, Yan Hendrika ##submission.copyrightStatement## https://jurnal.pkr.ac.id/index.php/JPK/article/view/790 Fri, 08 Dec 2023 02:26:48 +0000 The The Roles of Micro Nutrition Substances (Folic Acid, Vitamin C, Zink) on the Incidence of Anemia in Addolescent Girls https://jurnal.pkr.ac.id/index.php/JPK/article/view/719 <p><em><span lang="EN-US">Anemia is a condition of decreased red blood cell mass characterized by decreased hemoglobin, hematocrit and red blood cell count. Anemia in young women is at risk of impaired physical and mental function and can increase the risk of complications in the future. Based on the World Health Organization (WHO) report which states that more than 30% or 2 billion of the world's population is anemic. The prevalence of anemia in Indonesia is 21.7% with anemia sufferers aged 5-14 years of 26.4% and 57% aged 15-24 years. These data indicate that anemia is a nutritional problem that is often experienced by adolescents. The purpose of this study was to determine the relationship between micronutrients (folic acid, vitamin C, zinc) and the incidence of anemia in students majoring in nutrition at the Poltekkes Kemenkes Bengkulu in 2023. The research design used was cross sectional. The sampling technique used purposive sampling, with a total sample of 53 respondents. data collection using the food recall form. Data analysis using correlation test. The results showed that there was no relationship between micronutrients (folic acid, vitamin C, zinc) and the incidence of anemia (p&lt;0.05). It is recommended to examine other factors that cause anemia that are not examined, such as sleep patterns, knowledge, attitudes, behavior about anemia, especially in young women.</span></em></p> Viona Septi Yunita, Tonny Cortis Maigoda ##submission.copyrightStatement## https://jurnal.pkr.ac.id/index.php/JPK/article/view/719 Sat, 09 Dec 2023 04:14:16 +0000 Antenatal Screening of Pregnancy Risk Using KSPR in High Risk Pregnancy Women https://jurnal.pkr.ac.id/index.php/JPK/article/view/736 <p><em><span lang="EN">Throughout the world, the percentage of high-risk pregnancies ranges from 6% to 33% due to the situation and conditions of the pregnancy being at risk. The aim of this study was to carry out early antenatal screening using KSPR to determine the level of pregnancy risk experienced by pregnant women. This type of research uses a quantitative research design using analytical descriptive methods. The population in this study were high-risk pregnant women who came for a pregnancy check-up at the Obstetrics Clinic of Arifin Achmad Hospital, Pekanbaru City. The sampling technique uses a purposive sampling method. In this study, the results showed that the average respondent in the study was of healthy reproductive age, namely 20 -35 years. The average gestational age of respondents was in the third trimester, namely 28-42 weeks. A total of 57 respondents were in the Low Risk Pregnancy (KRR) category, 67 people were in the High Risk Pregnancy (KRT) category, and 54 people were in the Very High Risk Pregnancy (KRST) category. It can be concluded that the majority of respondents experienced the High Risk Pregnancy (KRT) category.</span></em></p> Elly Susilawati, Yanti Yanti ##submission.copyrightStatement## https://jurnal.pkr.ac.id/index.php/JPK/article/view/736 Sat, 16 Dec 2023 07:47:51 +0000 Comparison Of Dragon Fruit And Guava Juice With Iron Tablets In Increasing Hemoglobin Levels In Anemic Adolescent Girls https://jurnal.pkr.ac.id/index.php/JPK/article/view/800 <p><em><span lang="EN">Anemia is a health problem among teenagers, especially young women in Indonesia. As many as 27.2% of adolescent girls experience anemia. Efforts to overcome anemia in adolescents are carried out by meeting the iron requirements needed. This study aims to determine the comparison of dragon juice and guava juice with iron tablets in increasing hemoglobin levels in adolescent girls. This research is a quasi-experimental study with a two group post test design. Samples were taken purposively, with a total of 20 young women. Based on the results of the Independent T-test, there was a comparison of dragon fruit juice and guava juice with iron tablets (p=0.013). It is hoped that young women regularly consume nutrition containing iron and Vitamin C as needed to prevent anemia in young women.</span></em></p> Ani Laila, Septi Indah Permatasari, Meizy Rahmalia, Ari Susanti ##submission.copyrightStatement## https://jurnal.pkr.ac.id/index.php/JPK/article/view/800 Wed, 27 Dec 2023 07:51:30 +0000 Analysis Of Iron And Vitamin C Levels In "Guchiro" As An Altenative Food To Prevent Anemia In Pregnant Women https://jurnal.pkr.ac.id/index.php/JPK/article/view/739 <p><em><span lang="EN-US">According to the World Health Organization (WHO), around 35-37% of pregnant women experience iron deficiency and this increases with gestational age. Based on the results of research by Indonesian Ministry of Health, it is known that 48.9% of pregnant women in Indonesia experience anemia. Researchers are interested in making an innovative product of sago mochi with rosella (Hibiscus sabdariffa L.) flower jam as a non-pharmacological alternative to prevent anemia. The aim of this research is to analyze the levels of iron and vitamin C in "GUCHIRO" as a food to prevent anemia in pregnant women. This research was carried out from January 2023 to October 2023 at the integrated laboratory of the Riau Ministry of Health Polytechnic and the Pekanbaru BPPSI Laboratory. The sample in this research is the sample used is food made from processed sago and rosella flowers. To determine iron levels using the Atomic Absorption Spectrophotometry (SSA) method and vitamin C levels using the Absorption Spectrophotometry method which was carried out at the Center for Product Development and Industrial Standardization (BPPSI) in Pekanbaru city. The results of laboratory tests on Guchiro samples showed that Guchiro's iron levels were 88.5404 and vitamin C levels were 2.82%</span><span lang="EN-US">.</span></em></p> Findy Hindratni, Fathunikmah Fathunikmah, Septi Indah Permatasari ##submission.copyrightStatement## https://jurnal.pkr.ac.id/index.php/JPK/article/view/739 Wed, 27 Dec 2023 08:59:51 +0000 Workbook Effectiveness in Increasing the Knowledge and Attitude of Mental Health Cadres in Caring for People with Mental Disorders https://jurnal.pkr.ac.id/index.php/JPK/article/view/793 <p><em><span lang="EN-US">Sufferers of mental disorders are on the rise, posing challenges to individuals, families, and communities around the world. To be accepted back into society requires proper treatment through empowerment of the community into a mental health cadre, at the same time being an extension of the hand of puskesmas in the community. Mental health cadres can detect mental health problems using a mental health cadre workbook. The aim of this study is to look at the effectiveness of the workbook in improving knowledge and attitudes in treating people with mental disorders. Data collection using questionnaire sheets before and after giving an explanation. The initial step of data analysis is to test the normality of the data and obtain the result of normal distributed data (p value &gt; 0.05) and then perform a parametric test using the t-tst paired sample test to see the difference. The statistical test results show p value 0.001 for knowledge and p value 0.04 for attitude. There is a difference in knowledge and attitude between the two groups that are statistically significant.</span></em></p> Alice Rosy, Elmukhsinur Elmukhsinur ##submission.copyrightStatement## https://jurnal.pkr.ac.id/index.php/JPK/article/view/793 Thu, 28 Dec 2023 00:31:07 +0000 The The Relationship between Parenting, Exclusive Breasting and Quality of MP-ASI with Stunting Incidence in Under-Free Children Aged 6-12 Months https://jurnal.pkr.ac.id/index.php/JPK/article/view/718 <p style="font-weight: 400;"><em>Stunting is short stature that arises as a result of prolonged malnutrition. The indicator was the index (PB/U) according to WHO standards with growth criteria if the z-score PB/U -3 SD &lt;-2 SD Based on the results of a nutritional status survey in the Bengkulu City Health Office in 2022, the highest prevalence was in the Sawah Lebar Health Center WAS 15 children. The puprpose of the study was to determine the relationship between parenting style, exclusive breastfeeding and the quality of MP-asi with the incidence of stunting in toddlers aged 6-12 months in the working area of the Sawah Lebar Public Health Center in Bengkulu City in 2023. The research design was cross sectional. The sampling technique was simple random sampling, with a total sample was 59 toddlers. Collecting data with observational questionnairy.&nbsp; Chi square test was used in statistical analysis. The results showed that there was a relationship between parenting style, exclusive breastfeeding, and the quality of MP-ASI with the prevalence of stunting (p &lt;0.05) in toddlers aged 6-12 months. It is recommended to examine other factors that will lead to stunting such as family income, the number of family members and food intake.</em></p> Wina Puspita Sari, Tonny Cortis Maigoda ##submission.copyrightStatement## https://jurnal.pkr.ac.id/index.php/JPK/article/view/718 Fri, 29 Dec 2023 12:04:42 +0000 Antioxidant Activity of Edible Film Made From Catfish (Pangasius hypophthalmus) Gelatin Supplemented With Astaxanthin Using DPPH Method https://jurnal.pkr.ac.id/index.php/JPK/article/view/714 <p><em><span lang="EN-US">Edible film is a food packaging material that can be consumed along with the packaged product. In this study, the edible film was made from catfish gelatin and supplemented with astaxanthin, which possesses antioxidant activity. The objective of this research was to determine the antioxidant activity of catfish gelatin edible film supplemented with 0.5% astaxanthin and compared with comparative film. The antioxidant activity was measured using the DPPH method with a microplate reader at five concentrations of sample 62.5 mcg/ml, 125 mcg/ml, 250 mcg/ml, 500 mcg/ml, and 1000 mcg/ml. The results of the antioxidant activity test showed that the IC50 value of the edible film supplemented with astaxanthin was 251.06x10<sup>3 </sup>mcg/ml, while the comparative edible film was 133.12 mcg/ml. In conclusion, the edible film supplemented with astaxanthin exhibited weaker antioxidant activity compared to the comparative film</span><span lang="EN-US">.</span></em></p> Azlaini Yus Nasution, Intan Sri Wahyuni ##submission.copyrightStatement## https://jurnal.pkr.ac.id/index.php/JPK/article/view/714 Sat, 30 Dec 2023 00:00:00 +0000 Analysis of Pro-Environmental Behavior using the 5R method (Rethink, Reject, Reduce, Reuse, Recycle) towards Waste Management https://jurnal.pkr.ac.id/index.php/JPK/article/view/786 <p><em><span lang="EN-US">Pro-environmental waste management behavior can help reduce environmental damage or improve environmental conditions. The 5R method is rethink, reject, reduce, reuse, recycle. Preliminary data showed that 74% of the community had low knowledge of 5R, 78% had negative 5R attitudes, 55% had poor 5R actions in waste management. This research aims to determine the analysis of Pro-Environmental Behavior using the 5R method for Waste Management. This type of research is quantitative analytical cross sectional design. The research location is Rukun Tetangga.07/Rukun Warga 01 Perhentian Marpoyan Village. The population and sample are heads of families who live in RT 07/Rukun Warga 01, Perhentian Marpoyan Village, totaling 130 heads of families (Total Sampling). Questionnaire measuring tool. Computerized data processing. Univariate and bivariate data analysis (chi square test) CI 95%. The research results show that there is a relationship between pro-environmental behavior and the 5R method in waste management. Cooperation and integration of various parties, including the community, private sector and government, is needed to overcome this waste management.</span></em></p> Zulmeliza Rasyid ##submission.copyrightStatement## https://jurnal.pkr.ac.id/index.php/JPK/article/view/786 Mon, 19 Feb 2024 14:23:44 +0000 Analysis of Self-Medication Knowledge about Gastritis Among Vocational School Students https://jurnal.pkr.ac.id/index.php/JPK/article/view/798 <p><em><span lang="EN">This study aims to analyze the level of knowledge on self-medication for gastritis among students at SMK Abdurrab and SMK Taruna Satria in Pekanbaru, Riau province, in 2023. Gastritis is a commonly self-treated condition, especially among adolescents, due to factors such as irregular eating patterns, unhealthy lifestyles, and increased activities. Proper self-medication can significantly contribute to national health maintenance, but irrational drug use can have negative consequences. Data was collected using consecutive sampling techniques with 171 respondents and a questionnaire as the research instrument. Data analysis employed descriptive analysis. The results indicated that the level of knowledge among SMK Abdurrab students regarding self-medication for gastritis was categorized as good for 57 respondents (68.7%) and fair for 26 respondents (31.3%). Meanwhile, SMK Taruna Satria students' knowledge levels were categorized as good for 24 respondents (27.3%), fair for 30 respondents (34.1%), and poor for 34 respondents (38.6%). A comparison of their knowledge levels in the good category showed that SMK Abdurrab students were 42% higher than SMK Taruna Satria students. In the fair category, SMK Taruna Satria students were 3% higher than SMK Abdurrab students, while in the poor category, it was only applicable to SMK Taruna Satria students at 39%</span><span lang="EN-US">.</span></em></p> Isna Wardaniati, Siti Nurhaliza, Denia Pratiwi ##submission.copyrightStatement## https://jurnal.pkr.ac.id/index.php/JPK/article/view/798 Tue, 20 Feb 2024 04:09:00 +0000 Literature Review: Effect of Pegagan Embun (Hydrocotyle sibthorpioides Lam.) Extract on NK and CD8 Cell Activity https://jurnal.pkr.ac.id/index.php/JPK/article/view/644 <p><span lang="EN-US">There have been many traditional plants used for treatment, one plant that is widely used by the community for treatment is Hydrocotile sibthorpioides L. which is efficacious as an immunomodulator. In this plant, there are flavonoid compounds, namely rutin which has activity to increase the body's immune system, especially in NK and CD8 cells. NK (Natural Killer) and CD8 (Cluster of Differentiation 8) cells are components of the immune system that play an important role in immunomodulatory activity. This article review was conducted to obtain information on the effect of Hydrocotile sibthorpioides L. extract on NK and CD8 cell activity in the body. The writing method in making this research article review is comparative, which is taken from a collection of national journals and international journals.&nbsp; Various research results that have been obtained state that Hydrocotile sibthorpioides L. extract can affect the activity of NK and CD8 cells in improving the immune system.</span></p> Sri Gusriyani, Yufri Aldi, Salman Umar, Afriwardi Afriwardi ##submission.copyrightStatement## https://jurnal.pkr.ac.id/index.php/JPK/article/view/644 Thu, 09 Nov 2023 08:04:38 +0000 Literature Review: Ice Cube Therapy to Reduce Thirst in Patients Undergoing Hemodialysis https://jurnal.pkr.ac.id/index.php/JPK/article/view/652 <p><em>Chronic kidney failure is a malfunction of the kidneys which occurs over a relatively long period of time, this is the cause of reduced individual ability to maintain metabolism, fluid balance in the body which will then cause high urea values. Hemodialysis (HD) is an attempt to replace kidney function in filtering metabolic wastes, water and maintaining electrolyte levels in the body through a semi-shift membrane called Dalizer. . Ice Cubes therapy can help reduce thirst and freshen the throat. Ice cubes therapy is done by sucking ice cubes, where ice cubes can give a fresher feeling than drinking small amounts of mineral water, gargling with boiled water, gargling with medicines and others. To identify the effect of ice cube's on efforts to reduce thirst in patients undergoing hemodialysis. Data collection used the literature review study method using the Ebsco, Google Schooler, and Elsevier databases. With keywords: Ice Cube's Therapy, Hemodialysis Patients, Thirst with limited articles from 2018-2023. Obtained from 10 articles with 148 respondents in the Pretest Posttest research design and 4 respondents with a case study research design showing that there was an effect of ice cube's therapy on decreasing thirst in CKD patients undergoing Hemodialysis. In this literature review, it was found that there was an effect of ice cube's therapy on reducing thirst in CKD patients who were undergoing hemodialysis.</em></p> M. Rezza Januar Saputra, Sumardino Sumardino, Akhmad Rifai, Sugiyarto Sugiyarto ##submission.copyrightStatement## https://jurnal.pkr.ac.id/index.php/JPK/article/view/652 Mon, 13 Nov 2023 03:27:13 +0000 Literature Review: Multicomponent Crystal of Active Pharmaceutical Ingredients to Improve the Solubility https://jurnal.pkr.ac.id/index.php/JPK/article/view/683 <p>The purpose of this review was to<span lang="EN-US"> discu</span>s<span lang="EN-US">s</span> about<span lang="EN-US">s active pharmaceutical ingredients (API), formulations of drugs that are poorly soluble in water using various coformers and various methods of forming multicomponent crystals to increase the solubility of API. The formula used is equivalent in molecular weight between the active pharmaceutical ingredients (API) and coformers, using solvent evaporation and solvent drop grinding methods. A series of characterizations using X-ray Diffraction (XRD), differential scanning calorimetry (DSC), Fourier transform infrared (FTIR) and Scanning electron microscopy (SEM) to confirm the formation of multicomponent crystals. The </span>analysis from the results of the research show <span lang="EN-US">an increase in the solubility of API in water,</span> that is <span lang="EN-US">1.3 </span>up to <span lang="EN-US">115 times compared to </span>intact<span lang="EN-US">substances.</span></p> Ahdi Dinil Haq AH, Salman Umar, Erizal Zaini ##submission.copyrightStatement## https://jurnal.pkr.ac.id/index.php/JPK/article/view/683 Mon, 13 Nov 2023 07:38:09 +0000 Literature Review: Application Lyotropic Liquid Crystals in Topical and Transdermal Drug Delivery Systems https://jurnal.pkr.ac.id/index.php/JPK/article/view/681 <p><span lang="EN-US">This review article discusses the composition, formula, characterization, lyotropic liquid crystals which are formulated in topical and transdermal preparations with different liquid crystal phase carriers. Lyotropic liquid crystals have considerable potential in drug delivery systems. Lyotropic liquid crystals can be characterized by polarized light microscopy (PLM), small-angle X-ray scattering (SAXS), atomic force microscopy (AFM), thermogram electron microscopy (TEM), particle size, viscosity, drug release studies, drug permeation studies. . The formation of liquid crystals can be ascertained by observing birefringence using PLM or SAXS. This review also focuses on the structural classification of lyotropic liquid crystals into cubic, lamellar, and hexagonal phases. The structure of these phases is affected by the addition of surfactants, which include a variety of non-toxic, biodegradable lipids and also enhance drug solubility, drug permeation, bioavailability, and drug efficacy.</span></p> Nola Rahmadasmi, Erizal Zaini, Rini Agustin ##submission.copyrightStatement## https://jurnal.pkr.ac.id/index.php/JPK/article/view/681 Fri, 24 Nov 2023 00:00:00 +0000