Antihypertension Activity of Gynura procumbens (L.) Merr. Extract On Blood Pressure And Monoxide Nitrogen Levels In Male White Rats
Keywords:
Gynura procumbens, Hypertension, nitrogen monoxide
Abstract
Hypertension is closely related to vasodilation disorders because of the decreased availability of nitrogen monoxide (NO). The purpose of this study was to determine the decrease in blood pressure and nitrogen monoxide (NO) levels in rats after administration of Gynura procumbens leaves extract. The results showed that the administration of Gynura procumbens leaves extracts significantly reduced blood pressure and increased NO levels. From the results of Duncan's test, it was found that the dose of 300mg / Kg BW showed a better effect on increasing NO levels (p <0.05). From the results of the study, it can be concluded that the ethanol extract of Gynura procumbens leaves has an antihypertensive activity that can reduce blood pressure and increase the NO level.
References
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[15] Mi-Ja, K., Jae, L.H., Wiryowidagdo, S., Kyung, K.H, Antihypertensive Effects of Gynura procumbens Extract in Spontaneously Hypertensive Rats, J Med Food, 9(4), 587-590, 2006.
[2] WHO, World Health Organization-International Society of Hypertension Guidelines Far The Management of Hypertension, Journal of Hypertension 17,151-183., 1999.
[3] Rahimmanesh, I, Shahrezaei, M., & Rashidi, B, High blood pressure and endothelial dysfunction: effects of high blood pressure medications on endothelial dysfunction and new treatments, Journal of Research in Medical Sciences, 2, 291-311, 2012.
[4] Astutik, P., Wirjatmadi, B., Adriani, M., Peranan kadar nitrit oksida (NO) darah dan asupan lemak pada pasien hipertensi dan tidak hipertensi. Jurnal Gizi Klinik Indonesia, 10, (2), 55-60, 2013.
[5] Fujiwara, N, Osanai, T, Kamada, T, Katoh, T, Takahashi, K., & Okumura, K, Study on the relationship between plasma nitrite and nitrate level and salt sensitivity in human hypertension modulation of nitric oxide synthesis by salt intake. J. Circ. 101,(8), 856-861, 2000.
[6] Higashi, Y, Oshima, T, Watanabe, M., Matsuura, H, & Kajiyama, G, Renal response to L-arginine in salt-sensitive patients with essential hypertension. Hypertension, 27, 643-648, 1996.
[7] Boegehold, M, D., & Kotchen, T, A., Importance of Dietary Chloride for Salt Sensitivity of Blood Pressure.American Heart Association,17, (1), 158-161, 1991.
[8] Departemen Kesehatan Republik Indonesia, Farmakope Herbal Indonesia. (Edisi 1). Jakarta: Departemen Kesehatan Republik Indonesia, 2008.
[9] Kaewseejan, N, Puangpronpitag D, Nakornriab, M, Evaluation of phytochemical composition and antibacterial property of Gynura procumbens extract. Asian J. Plant Sci. 11, 77-82, 2012.
[10] Firmansyah, R. R., Hakim, R., & Damayanti, D, S., Efek Antihipertensi Dekokta Daun Sambung Nyawa (Gynura Procumbens) melalui Penghambatan ACE (Studi In Silico). Malang: Universitas Islam Malang, 2015.
[11] Kementerian Kesehatan Republik Indonesia, Farmakope Herbal Indonesia, (Edisi 1). Jakarta: Departemen Kesehatan Republik Indonesia, 2010.
[12] Sun, J, Zhang, X, Broderick, M, & Fein, H., Measurement of nitric oxide production in biological systems by using griess reaction assay. Sensors, 3,(8), 276-284, 2003.
[13] Synder, S, H, & Bredt, D, S., Biological roles of nitric oxide. Scientific American, 266, (5), 68 – 77, 1992.
[14] Taddei, S, Virdis, A, Ghiadoni, L, & Salvetti, A., The role of endothelium in human hypertension. Curr. Opin. Nephrol. Hypertensi, 7,(2), 203-209, 1998.
[15] Mi-Ja, K., Jae, L.H., Wiryowidagdo, S., Kyung, K.H, Antihypertensive Effects of Gynura procumbens Extract in Spontaneously Hypertensive Rats, J Med Food, 9(4), 587-590, 2006.
Published
2021-07-06
How to Cite
UthiaR., YulianaD., & KardelaW. (2021). Antihypertension Activity of Gynura procumbens (L.) Merr. Extract On Blood Pressure And Monoxide Nitrogen Levels In Male White Rats. JPK : Jurnal Proteksi Kesehatan, 9(2), 25-31. https://doi.org/10.36929/jpk.v9i2.309
Section
Articles
