Pengembangan Acne Patch Mengandung Kombinasi Minyak Sereh dan Minyak Kunyit: Karakterisasi dan Aktivitas Antibakteri

Yan Hendrika; Yunita Adriani Safitri

Penulis

Yan Hendrika
Universitas Abdurrab , Universitas Abdurrab, Pekanbaru, Indonesia
Yunita Adriani Safitri
Universitas Abdurrab, Pekanbaru, Indonesia

Kata Kunci:

Jerawat, patch, minyak sereh, minyak kunyit, antibakteri

Abstrak

Jerawat (Acne vulgaris) merupakan penyakit kulit yang umum berkaitan dengan proliferasi Propionibacterium acnes. Minyak sereh wangi dan minyak kunyit berpotensi sebagai agen antibakteri alami untuk sediaan topikal antijerawat. Penelitian ini bertujuan mengembangkan acne patch yang mengandung kombinasi kedua minyak atsiri serta mengevaluasi karakteristik fisikokimia dan aktivitas antibakterinya. Acne patch diformulasikan menggunakan matriks natrium alginat, kemudian dievaluasi meliputi organoleptis, ketebalan, pH, daya lipat, keseragaman bobot, kadar kelembapan, dan aktivitas antibakteri terhadap P. acnes menggunakan metode difusi agar. Seluruh formula memenuhi persyaratan organoleptis, ketebalan (0,11–0,14 mm), pH (6,14–6,75), daya lipat (>300 kali), dan keseragaman bobot, namun kadar kelembapan masih melebihi batas yang dipersyaratkan. Kombinasi minyak sereh wangi 3% dan minyak kunyit 6% menunjukkan aktivitas antibakteri tertinggi dalam bentuk minyak atsiri (12,68 mm), tetapi tidak menghasilkan zona hambat setelah diformulasikan menjadi acne patch. Hasil ini menunjukkan perlunya optimasi formulasi untuk meningkatkan pelepasan senyawa aktif dan efektivitas antibakterinya.

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Referensi

[1] H. A. Heng and F. T. Chew, “Systematic review of the epidemiology of acne vulgaris,” Scientific Reports, vol. 10, no. 1, p. 5754, 2020.

[2] A. L. Zaenglein et al., “Guidelines of care for the management of acne vulgaris,” Journal of the American Academy of Dermatology, vol. 74, no. 5, pp. 945–973, 2016.

[3] S. Kurokawa, N. Nakase, A. Deguchi, H. A. A. Kawabata, and K. Oiso, “New developments in our understanding of acne pathogenesis and treatment,” Experimental Dermatology, vol. 18, no. 10, pp. 821–832, 2009.

[4] B. Sevimli-Dikicier, “Topical treatment of acne vulgaris: Efficiency, side effects and adherence rate,” Journal of International Medical Research, vol. 47, no. 7, pp. 2987–2992, 2019.

[5] A. Tan, B. Schlosser, and A. Paller, “A review of diagnosis and treatment of acne in adult female patients,” International Journal of Women's Dermatology, vol. 4, no. 2, pp. 56–71, 2018.

[6] A. F. Burt, “Essential oils: Their antibacterial properties and potential applications in foods,” International Journal of Food Microbiology, vol. 94, pp. 223–253, 2004.

[7] P. Prakash, N. Gupta, and S. Gupta, “Therapeutic uses of Curcuma longa (turmeric),” Journal of Herbal Medicine, vol. 11, pp. 1–8, 2018.

[8] A. Sharifi-Rad et al., “Turmeric and its major compound curcumin on health,” Frontiers in Pharmacology, vol. 11, p. 01021, 2020.

[9] J. Boateng and H. Catanzano, “Advanced therapeutic dressings for effective wound healing,” Journal of Pharmaceutical Sciences, vol. 104, no. 11, pp. 3653–3680, 2015.

[10] N. Dhivya, V. Padma, and E. Santhini, “Wound dressings – A review,” BioMedicine, vol. 5, no. 4, pp. 22–28, 2015.

[11] R. Nurfadilah, L. R. Rizkuloh, and A. Nofriyaldi, “Formulation and antibacterial activity test of acne patch preparations made from ethanol extract of clove leaves against Propionibacterium acnes,” Jurnal Farmasi & Sains Indonesia, vol. 8, no. 1, pp. 145–155, 2025.

[12] S. E. Priani, R. F. Nurasyfa, G. C. E. Darma, S. P. Fitraningsih, L. Syafnir, and R. Prayitno, “Antibacterial activity of rosemary oil against Propionibacterium acnes and the formulation into nanoemulsion system,” Indonesian Journal of Pharmaceutical Science and Technology, vol. 10, no. 2, pp. 90–101, 2023.

[13] R. G. Santos et al., “Essential oils as antimicrobial agents: Challenges in formulation and delivery,” Pharmaceutics, vol. 13, no. 12, pp. 1–27, 2021.

[14] A. A. Ribeiro et al., “Advances in essential oil-based drug delivery systems,” International Journal of Pharmaceutics, vol. 615, p. 121495, 2022.

[15] A. Simanullang et al., “Formulation and evaluation of herbal acne patch,” Jurnal Farmasi Indonesia, vol. 21, no. 2, pp. 85–94, 2024.

[16] D. Kristianti et al., “Physical evaluation of transdermal patch preparations,” Pharmaciana, vol. 14, no. 1, pp. 15–24, 2024.

[17] N. Fitriana et al., “Evaluation of topical patch preparations,” Majalah Farmasetika, vol. 9, no. 2, pp. 77–86, 2024.

[18] N. Aini et al., “Evaluation of polymeric film dosage forms,” Jurnal Ilmiah Farmasi, vol. 19, no. 3, pp. 140–149, 2023.

[19] R. Adiaswati et al., “Evaluation of moisture content in polymeric film preparations,” International Journal of Applied Pharmaceutics, vol. 12, no. 5, pp. 75–81, 2020.

[20] CLSI, Performance Standards for Antimicrobial Susceptibility Testing, 33rd ed. Wayne, PA, USA: Clinical and Laboratory Standards Institute, 2023.

[21] I. Indrayani, “Antibacterial activity assay using agar diffusion method,” Jurnal Farmasi Indonesia, vol. 16, no. 1, pp. 52–60, 2019.

[22] H. Wijaya et al., “Application of One-Way ANOVA in pharmaceutical research,” Journal of Applied Statistics, vol. 11, no. 2, pp. 67–75, 2023.

[23] N. Aji, A. Puspitasari, H. Nafisah, and L. H. V. Armilda, “Antioxidant and anti-Propionibacterium acnes activities of citronella oil and clove oil, and their formulation into emulgel,” PHARMACY: Jurnal Farmasi Indonesia, vol. 20, no. 1, pp. 64–70, 2023.

[24] A. F. Burt, “Essential oils: Their antibacterial properties and potential applications in foods,” International Journal of Food Microbiology, vol. 94, pp. 223–253, 2004.

[25] A. Sharifi-Rad et al., “Turmeric and its major compounds: Biological activities and therapeutic potential,” Frontiers in Pharmacology, vol. 11, 2020.

[26] A. I. Lopes et al., “Alginate edible films containing essential oils: Characterization and bioactive potential,” Polymers, vol. 17, no. 9, p. 1188, 2025.

[27] A. I. Lopes et al., “Alginate edible films containing essential oils: Characterization and bioactive potential,” Polymers, vol. 17, no. 9, p. 1188, 2025.

[28] J. Boateng and H. Catanzano, “Advanced therapeutic dressings for effective wound healing,” Journal of Pharmaceutical Sciences, vol. 104, no. 11, pp. 3653–3680, 2015.

[29] S. Dash, P. Murthy, L. Nath, and P. Chowdhury, “Kinetic modeling on drug release from controlled drug delivery systems,” Acta Poloniae Pharmaceutica, vol. 67, no. 3, pp. 217–223, 2010.

[30] R. G. Santos et al., “Essential oils as antimicrobial agents: Challenges in formulation and delivery,” Pharmaceutics, vol. 13, no. 12, 2021.

[31] A. A. Ribeiro et al., “Advances in essential oil-based drug delivery systems,” International Journal of Pharmaceutics, vol. 615, p. 121495, 2022.

[32] A. I. Lopes et al., “Alginate edible films containing essential oils: Characterization and bioactive potential,” Polymers, vol. 17, no. 9, p. 1188, 2025.

[33] CLSI, Performance Standards for Antimicrobial Susceptibility Testing, 33rd ed. Wayne, PA, USA: Clinical and Laboratory Standards Institute, 2023.

[34] J. Boateng and H. Catanzano, “Advanced therapeutic dressings for effective wound healing,” Journal of Pharmaceutical Sciences, vol. 104, no. 11, pp. 3653–3680, 2015.

[35] A. Siepmann and J. Siepmann, “Mathematical modeling of drug delivery,” International Journal of Pharmaceutics, vol. 364, pp. 328–343, 2008.

[36] S. E. Priani et al., “Antibacterial activity of rosemary oil against Propionibacterium acnes and the formulation into nanoemulsion system,” Indonesian Journal of Pharmaceutical Science and Technology, vol. 10, no. 2, pp. 90–101, 2023.